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Anaconda, Click, and Drugs: Treatment Can it be cured? Yes Chlamydia Antibiotics azithromycin, doxycycline, erythromycin, levofloxacin or ofloxacin Gonorrhea Yes Antibiotics usually ceftriaxone and azithromycin but antibiotic resistance is increasing Hepatitis B 3 No Antiviral drugs and but most people will recover on their own; about 5% become chronically infected immune modulators tenofovir, entecavir, PEGylated interferon Hepatitis C So Sometimes cure rates are not 100% but a cure is possible Antiviral drugs drug choice depends on specific genotype of virus Herpes 0 but outbreaks usually reduce in severity/frequency over time (even without treatment) Antiviral drugs acyclovir, valacyclovir, and famciclovir Highly Active Antiretroviral Therapy (HAART) many different drug "cocktails" HIV/AIDS No but treatment greatly extends life expectancy (up to 50 years after diagnosis) No but most people will recover on their own; cancer screening is important Yes HPV None but genital warts can be removed Pubic Lice Topical treatment permethrin or pyrethrins with piperonyl butoxide Antibiotics penicillin, doxycycline, tetracycline Syphilis Yes Trichomoniasis Yes Antiparasitic medication metronidazole pervocracy: I feel like there’s a lot of infographics out there about STI prevention, but not enough about what happens if you already have one.  (The answer is not “you give up because your life is over.”)  So here, have some education! Click to make text bigger.
Anaconda, Click, and Drugs: Treatment
 Can it be
 cured?
 Yes
 Chlamydia
 Antibiotics
 azithromycin, doxycycline,
 erythromycin, levofloxacin or
 ofloxacin
 Gonorrhea
 Yes
 Antibiotics
 usually ceftriaxone and
 azithromycin
 but antibiotic resistance is
 increasing
 Hepatitis B
 3 No
 Antiviral drugs and
 but most people will recover on
 their own; about 5% become
 chronically infected
 immune modulators
 tenofovir, entecavir, PEGylated
 interferon
 Hepatitis C So
 Sometimes
 cure rates are not 100% but a cure
 is possible
 Antiviral drugs
 drug choice depends on specific
 genotype of virus
 Herpes
 0
 but outbreaks usually reduce in
 severity/frequency over time (even
 without treatment)
 Antiviral drugs
 acyclovir, valacyclovir, and
 famciclovir
 Highly Active
 Antiretroviral
 Therapy (HAART)
 many different drug "cocktails"
 HIV/AIDS
 No
 but treatment greatly extends life
 expectancy (up to 50 years after
 diagnosis)
 No
 but most people will recover on
 their own; cancer screening is
 important
 Yes
 HPV
 None
 but genital warts can be removed
 Pubic Lice
 Topical
 treatment
 permethrin or pyrethrins with
 piperonyl butoxide
 Antibiotics
 penicillin, doxycycline, tetracycline
 Syphilis
 Yes
 Trichomoniasis
 Yes
 Antiparasitic
 medication
 metronidazole
pervocracy:
I feel like there’s a lot of infographics out there about STI prevention, but not enough about what happens if you already have one.  (The answer is not “you give up because your life is over.”)  So here, have some education!
Click to make text bigger.

pervocracy: I feel like there’s a lot of infographics out there about STI prevention, but not enough about what happens if you already have ...

Bbb, Bilbo, and Drugs: INHIBIT CLASIFICATION ANTIBIOTICS Beta-Lactamase inhib Clavulanic Acid Penicinillase - Sensible Ampicillin Amoxicillin Aminopenicillins rum Natural Penicillins Penicillin G: Na, K, Procainic, Benzathine (IV, IM) Penicinillase - Resistant (very narrow spectrum) Antipseudomonal (extended spectrum) Penicillins (narrow spectrum) Penicillin VK: VO Oxacillin Dicloxacillin Carboxipenicillins Ureidopenicillins 1° Generation carcillin Carbenicillin Piperacillin Cephalexine Cephradrine Cefuroxime Cefadroxil Cefprozil Cefotetan 2° Generation Cefoperazone Ceftriaxone Cefpodoxime Ceftizoxime Ceftibuten Loracarbef Cefixime Cefotaxime Ceftazidime Cephalosporins 3° Generation Cefditoren Cefpirome* Ceftolozane 4° Generation Cefepime 5° Generation Carbapenems Monobactams Glycopeptides Meropenem Ertapenem DoripenemImipenem Cylastatine Aztreonam Telavancin Dalbavancin Oritavancin Isoniazid Vancomycin Daptomycin Gentamicin Neomycin Minocycline Demeclocylin* Tobramycin Amino glycosides Tetracyclins Streptomycin Doxycycline Tetracyclin Tigecyclirn Linezolid Oxazolidonones Streptogramins Quinupristin/Dalfopristin Cloramphenicol Macrolides Lincosamides 50S Erythromycin Azithromycin Clarithromycin Clindamycin Lincomycin DNA topoisomerases Moxifloxacin Ofloxacin Levofloxacin Enofloxacin Fluorquinolones Ciprofloxacin Norfloxacin Gemifloxacin Sparfloxacin Quinolones Nalidixic Acid Sulfonamides Sulfamethoxazole Ag Sulfadiazine Sulfasalazine Sulfisoxazole Trimethoprim (TMP) Metronidazole DHFR inhibitors Pyrimethamine DNA (damage) mRNA synth.Rifampim Nitroimidazoles <p><a href="http://mynotes4usmle.tumblr.com/post/94603349785/antibiotics-cheat-sheet-also-remember" class="tumblr_blog">mynotes4usmle</a>:</p> <blockquote><p><b>ANTIBIOTICS CHEAT SHEET :)</b></p> <p>Also, REMEMBER!!!!</p> <p><b>* Sulfonamides</b> compete for albumin with:</p> <ul><li><b>Bilirrubin: </b>given in 2°,3°T, high risk or indirect hyperBb and kernicterus in premies</li> <li><b>Warfarin: </b>increases toxicity: bleeding</li> </ul><p>* <b>Beta-lactamase (penicinillase) Suceptible:</b></p> <ul><li>Natural Penicillins (G, V, F, K)</li> <li>Aminopenicillins (Amoxicillin, Ampicillin)</li> <li>Antipseudomonal Penicillins (Ticarcillin, Piperacillin)</li> </ul><p>* <b>Beta-lactamase (penicinillase) Resistant:</b></p> <ul><li>Oxacillin, Nafcillin, Dicloxacillin</li> <li>3°G, 4°G Cephalosporins</li> <li>Carbapenems </li> <li>Monobactams</li> <li>Beta-lactamase inhibitors</li> </ul><p><b>* Penicillins</b> enhanced with:</p> <ul><li><b>Clavulanic acid &amp; Sulbactam</b> (both are suicide inhibitors, they inhibit beta-lactamase)</li> <li><b>Aminoglycosides</b> (against enterococcus and psedomonas)</li> </ul><p>* <b>Aminoglycosides </b>enhanced with <b>Aztreonam</b></p> <p><b>*</b> Penicillins: renal clearance EXCEPT <b>Oxacillin &amp; Nafcillin </b>(bile)</p> <p><b>*</b> Cephalosporines: renal clearance EXCEPT <b>Cefoperazone &amp; Cefrtriaxone </b>(bile)</p> <p>* Both inhibited by <b>Probenecid</b> during tubular secretion.</p> <p><b>* 2°G Cephalosporines: </b>none cross BBB except <b>Cefuroxime</b></p> <p><b>* 3°G Cephalosporines: </b>all cross BBB except <b>Cefoperazone</b> bc is highly highly lipid soluble, so is protein bound in plasma, therefore it doesn’t cross BBB.</p> <p><b>* Cephalosporines </b>are &quot;<b>LAME</b>“ bc they  do <b>not cover</b> this organisms </p> <ul><li><b>L  </b>isteria monocytogenes</li> <li><b>A  </b>typicals (Mycoplasma, Chlamydia)</li> <li><b>M </b>RSA <b>(except Ceftaroline, 5°G)</b></li> <li><b>E </b> nterococci</li> </ul><figure class="tmblr-full" data-orig-height="282" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/fefa0e57bd8663f41e32258e9f58f135/tumblr_inline_mvv7hx19421r9he9m.gif"><img src="https://78.media.tumblr.com/cdf6c898d35c4d91aa1f3e6bd9a98462/tumblr_inline_p7g6owpmSr1scxgwx_540.gif" alt="image" data-orig-height="282" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/fefa0e57bd8663f41e32258e9f58f135/tumblr_inline_mvv7hx19421r9he9m.gif"/></figure><p>* Disulfiram-like effect: <b>Cefotetan </b>&amp; <b>Cefoperazone </b>(<i><b><a href="http://mynotes4usmle.tumblr.com/post/72610336163/drugs-that-cause-disulfiram-like-effects-mnemonic#.U98PPPl5Mms">mnemonic</a></b></i>)<b><br/></b></p> <p><b>* Cefoperanzone: </b>all the exceptions!!!</p> <ul><li>All 3°G cephalosporins cross the BBB except Cefoperazone.</li> <li>All cephalosporins are renal cleared, except Cefoperazone.</li> <li>Disulfiram-like effect</li> </ul><p>* Against <b><i>Pseudomonas</i></b>:</p> <ul><li>3°G <b>Cef taz idime </b>(taz taz taz taz)</li> <li>4°G <b>Cefepime, Cefpirome </b>(not available in the USA)</li> <li><b>Antipseudomonal penicillins</b></li> <li><b>Aminoglycosides </b>(synergy with beta-lactams)</li> <li><b>Aztreonam </b>(pseudomonal sepsis)</li> </ul><p>* Covers <b>MRSA: </b><b>Ceftaroline </b>(rhymes w/ Caroline, Caroline the 5°G Ceph), <b>Vancomycin, </b><b>Daptomycin, </b><b>Linezolid, </b><b>Tigecycline.</b></p> <p><b>* </b>Covers <b>VRSA: Linezolid, Dalfopristin/Quinupristin</b></p> <p><b>* Aminoglycosides:</b> decrease release of ACh in synapse and act as a Neuromuscular blocker, this is why it enhances effects of muscle relaxants.</p> <p><b>* DEMECLOCYCLINE: </b>tetracycline that’s not used as an AB, it is used as tx of SIADH to cause Nephrogenic Diabetes Insipidus (inhibits the V2 receptor in collecting ducts)</p> <p>* Phototoxicity: <b>Q</b> ue<b> S T </b> ion?</p> <ul><li><b>Q </b>uinolones</li> <li><b>S</b>ulfonamides</li> <li><b>T</b> etracyclines</li> </ul><figure class="tmblr-full" data-orig-height="281" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_n9rlcbPQ271r9he9m.gif"><img src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_p7g6owDZDE1scxgwx_540.gif" alt="image" data-orig-height="281" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_n9rlcbPQ271r9he9m.gif"/></figure><p>* <b><a href="http://mynotes4usmle.tumblr.com/post/62061356766/cyp450-inducers-inhibitors-mnemonic#.U-RmDfl5Mms">p450 inhibitors</a>:</b> Cloramphenicol, Macrolides (except Azithromycin), Sulfonamides</p> <p>* <b>Macrolides SE: Motilin</b> stimulation, <b>QT prolongation</b>, reversible <b>deafness</b>, <b>eosinophilia</b>, <b>cholestatic</b> hepatitis</p> <p>* <b>Bactericidal: </b>beta-lactams (penicillins, cephalosporins, monobactams, carbapenems), aminoglycosides, fluorquinolones, metronidazole.</p> <p><b>* Baceriostatic: </b>tetracyclins, streptogramins, chloramphenicol, lincosamides, oxazolidonones, macrolides, sulfonamides, DHFR inhibitors.</p> <p>* <b>Pseudomembranous colitis: </b>Ampicillin, Amoxicillin, Clindamycin, Lincomycin.</p> <p>* <b>QT prolongation: </b>macrolides, sometimes fluoroquinolones</p></blockquote>
Bbb, Bilbo, and Drugs: INHIBIT
 CLASIFICATION
 ANTIBIOTICS
 Beta-Lactamase inhib
 Clavulanic Acid
 Penicinillase - Sensible
 Ampicillin
 Amoxicillin
 Aminopenicillins
 rum
 Natural Penicillins Penicillin G: Na, K, Procainic, Benzathine (IV, IM)
 Penicinillase - Resistant (very narrow spectrum)
 Antipseudomonal (extended spectrum)
 Penicillins
 (narrow spectrum) Penicillin VK: VO
 Oxacillin
 Dicloxacillin
 Carboxipenicillins
 Ureidopenicillins
 1° Generation
 carcillin
 Carbenicillin
 Piperacillin
 Cephalexine
 Cephradrine
 Cefuroxime
 Cefadroxil
 Cefprozil
 Cefotetan
 2° Generation
 Cefoperazone Ceftriaxone
 Cefpodoxime Ceftizoxime
 Ceftibuten
 Loracarbef
 Cefixime
 Cefotaxime
 Ceftazidime
 Cephalosporins
 3° Generation
 Cefditoren
 Cefpirome*
 Ceftolozane
 4° Generation
 Cefepime
 5° Generation
 Carbapenems
 Monobactams
 Glycopeptides
 Meropenem
 Ertapenem DoripenemImipenem Cylastatine
 Aztreonam
 Telavancin
 Dalbavancin
 Oritavancin
 Isoniazid
 Vancomycin
 Daptomycin
 Gentamicin
 Neomycin
 Minocycline
 Demeclocylin*
 Tobramycin
 Amino
 glycosides
 Tetracyclins
 Streptomycin
 Doxycycline
 Tetracyclin
 Tigecyclirn
 Linezolid
 Oxazolidonones
 Streptogramins Quinupristin/Dalfopristin
 Cloramphenicol
 Macrolides
 Lincosamides
 50S
 Erythromycin
 Azithromycin
 Clarithromycin
 Clindamycin
 Lincomycin
 DNA
 topoisomerases
 Moxifloxacin
 Ofloxacin
 Levofloxacin
 Enofloxacin
 Fluorquinolones
 Ciprofloxacin
 Norfloxacin
 Gemifloxacin
 Sparfloxacin
 Quinolones
 Nalidixic Acid
 Sulfonamides
 Sulfamethoxazole
 Ag Sulfadiazine Sulfasalazine Sulfisoxazole
 Trimethoprim (TMP)
 Metronidazole
 DHFR inhibitors
 Pyrimethamine
 DNA (damage)
 mRNA synth.Rifampim
 Nitroimidazoles
<p><a href="http://mynotes4usmle.tumblr.com/post/94603349785/antibiotics-cheat-sheet-also-remember" class="tumblr_blog">mynotes4usmle</a>:</p>

<blockquote><p><b>ANTIBIOTICS CHEAT SHEET :)</b></p>
<p>Also, REMEMBER!!!!</p>
<p><b>* Sulfonamides</b> compete for albumin with:</p>
<ul><li><b>Bilirrubin: </b>given in 2°,3°T, high risk or indirect hyperBb and kernicterus in premies</li>
<li><b>Warfarin: </b>increases toxicity: bleeding</li>
</ul><p>* <b>Beta-lactamase (penicinillase) Suceptible:</b></p>
<ul><li>Natural Penicillins (G, V, F, K)</li>
<li>Aminopenicillins (Amoxicillin, Ampicillin)</li>
<li>Antipseudomonal Penicillins (Ticarcillin, Piperacillin)</li>
</ul><p>* <b>Beta-lactamase (penicinillase) Resistant:</b></p>
<ul><li>Oxacillin, Nafcillin, Dicloxacillin</li>
<li>3°G, 4°G Cephalosporins</li>
<li>Carbapenems </li>
<li>Monobactams</li>
<li>Beta-lactamase inhibitors</li>
</ul><p><b>* Penicillins</b> enhanced with:</p>
<ul><li><b>Clavulanic acid &amp; Sulbactam</b> (both are suicide inhibitors, they inhibit beta-lactamase)</li>
<li><b>Aminoglycosides</b> (against enterococcus and psedomonas)</li>
</ul><p>* <b>Aminoglycosides </b>enhanced with <b>Aztreonam</b></p>
<p><b>*</b> Penicillins: renal clearance EXCEPT <b>Oxacillin &amp; Nafcillin </b>(bile)</p>
<p><b>*</b> Cephalosporines: renal clearance EXCEPT <b>Cefoperazone &amp; Cefrtriaxone </b>(bile)</p>
<p>* Both inhibited by <b>Probenecid</b> during tubular secretion.</p>
<p><b>* 2°G Cephalosporines: </b>none cross BBB except <b>Cefuroxime</b></p>
<p><b>* 3°G Cephalosporines: </b>all cross BBB except <b>Cefoperazone</b> bc is highly highly lipid soluble, so is protein bound in plasma, therefore it doesn’t cross BBB.</p>
<p><b>* Cephalosporines </b>are &quot;<b>LAME</b>“ bc they  do <b>not cover</b> this organisms </p>
<ul><li><b>L  </b>isteria monocytogenes</li>
<li><b>A  </b>typicals (Mycoplasma, Chlamydia)</li>
<li><b>M </b>RSA <b>(except Ceftaroline, 5°G)</b></li>
<li><b>E </b> nterococci</li>
</ul><figure class="tmblr-full" data-orig-height="282" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/fefa0e57bd8663f41e32258e9f58f135/tumblr_inline_mvv7hx19421r9he9m.gif"><img src="https://78.media.tumblr.com/cdf6c898d35c4d91aa1f3e6bd9a98462/tumblr_inline_p7g6owpmSr1scxgwx_540.gif" alt="image" data-orig-height="282" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/fefa0e57bd8663f41e32258e9f58f135/tumblr_inline_mvv7hx19421r9he9m.gif"/></figure><p>* Disulfiram-like effect: <b>Cefotetan </b>&amp; <b>Cefoperazone </b>(<i><b><a href="http://mynotes4usmle.tumblr.com/post/72610336163/drugs-that-cause-disulfiram-like-effects-mnemonic#.U98PPPl5Mms">mnemonic</a></b></i>)<b><br/></b></p>
<p><b>* Cefoperanzone: </b>all the exceptions!!!</p>
<ul><li>All 3°G cephalosporins cross the BBB except Cefoperazone.</li>
<li>All cephalosporins are renal cleared, except Cefoperazone.</li>
<li>Disulfiram-like effect</li>
</ul><p>* Against <b><i>Pseudomonas</i></b>:</p>
<ul><li>3°G <b>Cef taz idime </b>(taz taz taz taz)</li>
<li>4°G <b>Cefepime, Cefpirome </b>(not available in the USA)</li>
<li><b>Antipseudomonal penicillins</b></li>
<li><b>Aminoglycosides </b>(synergy with beta-lactams)</li>
<li><b>Aztreonam </b>(pseudomonal sepsis)</li>
</ul><p>* Covers <b>MRSA: </b><b>Ceftaroline </b>(rhymes w/ Caroline, Caroline the 5°G Ceph), <b>Vancomycin, </b><b>Daptomycin, </b><b>Linezolid, </b><b>Tigecycline.</b></p>
<p><b>* </b>Covers <b>VRSA: Linezolid, Dalfopristin/Quinupristin</b></p>
<p><b>* Aminoglycosides:</b> decrease release of ACh in synapse and act as a Neuromuscular blocker, this is why it enhances effects of muscle relaxants.</p>
<p><b>* DEMECLOCYCLINE: </b>tetracycline that’s not used as an AB, it is used as tx of SIADH to cause Nephrogenic Diabetes Insipidus (inhibits the V2 receptor in collecting ducts)</p>
<p>* Phototoxicity: <b>Q</b> ue<b> S T </b> ion?</p>
<ul><li><b>Q </b>uinolones</li>
<li><b>S</b>ulfonamides</li>
<li><b>T</b> etracyclines</li>
</ul><figure class="tmblr-full" data-orig-height="281" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_n9rlcbPQ271r9he9m.gif"><img src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_p7g6owDZDE1scxgwx_540.gif" alt="image" data-orig-height="281" data-orig-width="500" data-orig-src="https://78.media.tumblr.com/7af835b2dc618c0aac3a1186d5ee68fb/tumblr_inline_n9rlcbPQ271r9he9m.gif"/></figure><p>* <b><a href="http://mynotes4usmle.tumblr.com/post/62061356766/cyp450-inducers-inhibitors-mnemonic#.U-RmDfl5Mms">p450 inhibitors</a>:</b> Cloramphenicol, Macrolides (except Azithromycin), Sulfonamides</p>
<p>* <b>Macrolides SE: Motilin</b> stimulation, <b>QT prolongation</b>, reversible <b>deafness</b>, <b>eosinophilia</b>, <b>cholestatic</b> hepatitis</p>
<p>* <b>Bactericidal: </b>beta-lactams (penicillins, cephalosporins, monobactams, carbapenems), aminoglycosides, fluorquinolones, metronidazole.</p>
<p><b>* Baceriostatic: </b>tetracyclins, streptogramins, chloramphenicol, lincosamides, oxazolidonones, macrolides, sulfonamides, DHFR inhibitors.</p>
<p>* <b>Pseudomembranous colitis: </b>Ampicillin, Amoxicillin, Clindamycin, Lincomycin.</p>
<p>* <b>QT prolongation: </b>macrolides, sometimes fluoroquinolones</p></blockquote>

mynotes4usmle: ANTIBIOTICS CHEAT SHEET :) Also, REMEMBER!!!! * Sulfonamides compete for albumin with: Bilirrubin: given in 2°,3°T, high ris...